• The so called driver hypothesis has been posited in

  2019-06-10

  

  The so-called driver CT-99021 has been posited in the recent years. Optical mapping studies in isolated sheep hearts have suggested that at least some cases of AF can be maintained by high-frequency reentrant sources (rotors), usually located in the posterior LA, which result in spatially distribute

• Recently emerging data suggest that lower frequency of IV

  2019-06-10

  

  Recently emerging data suggest that lower frequency of IV bisphosphonates in metastatic breast cancer has the same efficacy as monthly regimen [48]. ONJ on the other hand can be extremely symptomatic with a severely detrimental effect on quality of life. A case-control study based on risk factors f

• br Discussion Debate persists about how to

  2019-06-10

  

  Discussion Debate persists about how to best define the ER ECG pattern. There is consensus regarding definition of the malignant form of ER as a J-point elevation that could be (or not) associated with ST elevation [1]. In this case, a clear J-point elevation was seen, particularly in lead III (F

• HF is associated with the down regulation of multiple

  2019-06-06

  

  HF is associated with the down-regulation of multiple potassium (K) currents (i.e., Ito, IKs, IKr, IK1, and IKATP). The only K channel that is upregulated in HF is the small conductance Ca-activated K (SK) channel. The SK channel was originally found in most neurons. The increase in Cai evoked by th

• There have been some case

  2019-06-06

  

  There have been some case reports of RNRVAS [3,4], but the present case is the first report of RNRVAS exacerbating heart failure. After RNRVAS was avoided with NCAP, the state of his heart failure improved, indicating that RNRVAS was the trigger for the worsening heart failure. His bradycardia param

• br Discussion The differential diagnosis of ATA with a

  2019-06-06

  

  Discussion The differential diagnosis of ATA with a constant CS activation sequence following PV isolation for AF includes (a) AF originating from a non-PV focus [1], (b) focal ATA, and (c) macro-reentrant AFL of LA or RA origin [2–4]. First, the proximal-to-distal CS activation sequence during t

• br Conclusion br Conflict of interest br Introduction Recent

  2019-06-06

  

  Conclusion Conflict of interest Introduction Recent trials of the use of implantable electronic devices, including implantable cardioverter defibrillators (ICDs) and cardiac resynchronization therapy defibrillators (CRT-Ds) show survival benefits [1–3]. As a result, implantable electronic d

• br Material and methods br Results br

  2019-06-06

  

  Material and methods Results Discussion In our series, fracture progression was noted in 53% of the lesions and 5 patients presented with new fractures after RT. Previous studies reported on the rate of pathologic fractures after single or multifraction RT; however, they did not stratify be

• Nos anos de alguns setores da Igreja

  2019-06-06

  

  Nos anos de 1970 alguns setores da Igreja católica iniciaram uma nova etapa na ligação da instituição com as elites e a política. Outrora a Igreja era parte integrante desse arranjo, neste período se converteu em contestadora da acumulação financeira, das desigualdades, do latifúndio e da autoridade

• While it has been reported

  2019-06-06

  

  While it has been reported that the combination therapy of As2O3 and ATRA is highly effective not only as the front-line treatment [6], but also in relapsed and treatment-refractory APL patients [7], showing fewer adverse events than the combination of ATRA and chemotherapeutic drugs, the efficacy a

• In addition we evaluated the left atrium left

  2019-06-06

  

  In addition, we evaluated the left atrium–left ventricle contraction sequence caused by the interatrial conduction delay. When we performed AV sequential pacing using the nominal AV delay setting, left atrial contractions were significantly delayed and were almost simultaneous with the left ventricu

• This patient s shortest R R

  2019-06-06

  

  This patient\'s shortest R–R interval on ECG was about 200ms (300bpm), which indicated high risk of sudden cardiac death. The patient underwent catheter ablation. ACC/AHA/ESC guidelines for the management of patients with supraventricular arrhythmias [1], which include accessory pathway-mediated arr

• Introduction Ewing s sarcoma ES is

  2019-06-06

  

  Introduction Ewing\'s sarcoma (ES) is a high-grade neoplasm representing the second most common primary bone malignancy in both children and adults. With a peak incidence at 15 years, this disease accounts for 2% of childhood cancers [1–3]. ES is defined as a bone tumor which may occur at any site

• According to the labeling of dabigatran in Japan

  2019-06-06

  

  According to the labeling of dabigatran in Japan, patients to be considered for the prescription of the lower dose of 220mg/day are as follows: (1) aged ≥70 years, (2) with moderate renal impairment (ClCr 30–50mL/min), (3) concomitant use of a p-glycoprotein inhibitor, and (4) history of hemorrhage

• Despite our best efforts the cause

  2019-06-06

  

  Despite our best efforts, the cause of SCD in young individuals is sometimes not established; no cause is identified in up to 40% of cases. Importantly, whether a cause of death is established or not, the possibility of an underlying inherited cardiac disorder remains in many cases, including the po

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