• All photographs colour or black and white should be along

  2019-06-11

  

  All photographs—colour or black and white—should be , along with the required text and any supporting material for online publication. Please select Photograph as the article type. If a digital camera is used please set it to the highest possible quality setting and submit images as JPEG files. If

• In the present study we found that stathmin was significantl

  2019-06-11

  

  In the present study, we found that stathmin was significantly down-regulated upon treatment with a combination of Zol and gefitinib. The down-regulation of stathmin, which was not detected by 2-D DIGE after treatment with either agent alone, was considered to be attributable to cooperative effect o

• Tivantinib Real time quantitative polymerase chain

  2019-06-10

  

  Real-time quantitative polymerase chain reaction (RQ-PCR) was performed to quantify BCR/ABL1 transcript as described previously [1]. The quantitative results were expressed as percent ratios relative to an ABL1 internal control using the following formula (p210 BCR–ABL/ABL1×100×CF) [2]. The level of

• br Conclusion br Authors contribution

  2019-06-10

  

  Conclusion Authors’ contribution Competing interests Acknowledgments Case report Imatinib has radically changed prognosis in chronic-phase Chronic Myeloid Leukemia (CML), with 90% overall survival rate at 8yrs, and 40–70% of patients achieving a stable MMR [1]. Even better results hav

• Evidence of the efficacy of topiramate in PTC has been

  2019-06-10

  

  Evidence of the efficacy of topiramate in PTC has been reported in the literature [41,42]. The largest study, an open-label trial by Celebisoy and colleagues [41], demonstrated the non-inferiority of topiramate to acetazolamide in the management of idiopathic intracranial mao inhibitor in a populat

• Introduction This document addresses the indications for

  2019-06-10

  

  Introduction This document addresses the indications for diagnostic testing, the present state of prognostic risk stratification, and the treatment strategies that have been demonstrated to improve the clinical outcome of patients with VAs. In addition, this document includes recommendations for re

• Several cases of injury to the circumflex

  2019-06-10

  

  Several cases of injury to the circumflex artery owing to ablation of the lateral mitral isthmus and inside the CS have been reported. The circumflex artery and the CS share a close relationship. Takahashi et al. reported the first case of acute circumflex artery occlusion during CS ablation, which

• order UNC 0642 In addition our present findings demonstrated

  2019-06-10

  

  In addition, our present findings demonstrated that NOACs may offer advantages over warfarin therapy besides efficiency and safety. The time to ECV in the present OAC-naïve patients was significantly shorter in the NOAC group compared to the VKA group. This may be explained by the delayed achievemen

• Introduction Acute acalculous cholecystitis ACC is

  2019-06-10

  

  Introduction Acute acalculous cholecystitis (ACC) is defined as an acute necroinflammatory disease of the gallbladder in the absence of cholelithiasis and has a multifactorial pathogenesis [1]. ACC has very rarely been described in patients undergoing myelosuppressive chemotherapy for acute myelobl

• Two important issues affect our interpretation

  2019-06-10

  

  Two important issues affect our interpretation of these findings. First, many women chose institutional delivery (53% of deliveries were at hospitals in Sazawal and colleagues\' trial, and 64% in Semrau and colleagues\' trial). The latest WHO guidelines recommend application of chlorhexidine to the

• In patients with surgically corrected CHD the

  2019-06-10

  

  In patients with surgically corrected CHD, the anatomic position of the atriotomy scar as the arrhythmogenic substrate is commonly found in the free wall and not in the septum [8]. The cause of this large area of low voltage (“atrial myopathy”) is unclear. Possible explanations include interruption

• The so called driver hypothesis has been posited in

  2019-06-10

  

  The so-called driver CT-99021 has been posited in the recent years. Optical mapping studies in isolated sheep hearts have suggested that at least some cases of AF can be maintained by high-frequency reentrant sources (rotors), usually located in the posterior LA, which result in spatially distribute

• Recently emerging data suggest that lower frequency of IV

  2019-06-10

  

  Recently emerging data suggest that lower frequency of IV bisphosphonates in metastatic breast cancer has the same efficacy as monthly regimen [48]. ONJ on the other hand can be extremely symptomatic with a severely detrimental effect on quality of life. A case-control study based on risk factors f

• br Discussion Debate persists about how to

  2019-06-10

  

  Discussion Debate persists about how to best define the ER ECG pattern. There is consensus regarding definition of the malignant form of ER as a J-point elevation that could be (or not) associated with ST elevation [1]. In this case, a clear J-point elevation was seen, particularly in lead III (F

• HF is associated with the down regulation of multiple

  2019-06-06

  

  HF is associated with the down-regulation of multiple potassium (K) currents (i.e., Ito, IKs, IKr, IK1, and IKATP). The only K channel that is upregulated in HF is the small conductance Ca-activated K (SK) channel. The SK channel was originally found in most neurons. The increase in Cai evoked by th

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