• Both breast cancer and MM cause osteolytic lesions

  2019-06-13

  

  Both breast cancer and MM cause osteolytic lesions, inhibiting osteoblast differentiation and thereby tipping the balance in favour of osteoclastic activity. In contrast, prostate cancer predominantly causes osteoblastic bone disease. Interestingly, increased marrow adiposity has been associated wit

• After the RFCA neither sustained VT nor the VPCs

  2019-06-13

  

  After the RFCA, neither sustained VT nor the VPCs that triggered the VT were recorded. The patient was fitted with a WCD (LifeVest, Zoll, Pittsburgh, PA, USA) on the third day post-ablation, and sotalol 80mg a day was started. He was discharged from the coronary care unit the following day. During c

• The gallstone Lith gene map

  2019-06-13

  

  The gallstone (Lith) gene map has been updated, which lists all known genetic loci that confer gallstone susceptibility, as well as candidate genes in inbred strains of mice. Understanding molecular genetics of gallstone disease in mice will push for the identification of human Lith genes. In additi

• A substantial part of the

  2019-06-13

  

  A substantial part of the value of setting goals, targets, and indicators lies in the imperative to collect information for measurement and accountability —“what gets measured gets done”. The decision to exclude an indicator because it Sulfo-NHS-Biotin is less established is diametrically opposed t

• Development of an atrial esophageal

  2019-06-12

  

  Development of an atrial–esophageal fistula is one of the most dreaded complications of AF ablation [78]. A relatively large-scale nonrandomized study revealed that the anatomical risk factor of a small LA-to-esophageal distance was the most important factor in esophageal ulceration when using an ir

• Introduction Bone is a very

  2019-06-12

  

  Introduction Bone is a very dynamic tissue resulting from coordinated phases of formation and resorption called bone remodelling. Additional to its role in phosphocalcic homoeostasis, bone remodelling process is necessary for bone growth, for renewal of cellular and extracellular matrix components

• Demand for kidney transplantation for

  2019-06-12

  

  Demand for kidney transplantation for ESKD has already outstripped the supply of donated nucleoside transporters from living donors, notwithstanding the inadequate donor pool. End-of-life donation can potentially expand the donor pool but is less common. For example, in India, among the 12 294 rena

• Accordingly blockade of TL A Fas

  2019-06-12

  

  Accordingly, blockade of TL1A/Fas-L/TLR4 cascades and inhibition of the M1/Th1 differentiation associated with DcR3 might potentially rescue hepatic IR injury. However, the contribution of TL1A/Fas-L/TLR4 on the M1/M2 and Th1/Th2 balances, as well as pathogenic liver IR injury had never previously b

• Despite these recommendations diagnosing CIED infection coul

  2019-06-12

  

  Despite these recommendations, diagnosing CIED infection could be challenging. Early after implantation procedure it is important to differentiate CIED pocket infection from incisional erythema or superficial wound infection or stitch abscess. These cases usually resolve with local measures and some

• br Methods br Results The clinical

  2019-06-12

  

  Methods Results The clinical, genetic, electrocardiographic, and electrophysiological characteristics of the study patients are shown in Table 1. Eight of the 45 patients were symptomatic, having a history of syncope (n=3) or aborted SCD (n=5). The remaining 37 patients were asymptomatic, alth

• Introduction Dabigatran Boehringer Ingelheim Ingelheim Germa

  2019-06-12

  

  Introduction Dabigatran (Boehringer Ingelheim, Ingelheim, Germany) is a direct thrombin inhibitor, which can be orally administered, and is used to decrease the risk of ischemic stroke in patients with non-valvular atrial fibrillation (NVAF). In early phase studies of dabigatran in healthy men, ino

• br Malaria is a major public

  2019-06-12

  

  Malaria is a major public health problem and a leading cause of mortality worldwide, especially in sub-Saharan Africa, where 90% of the world\'s 627 000 malaria deaths occur every year. However, the disease is usually curable if diagnosed quickly. Diagnosis is often made on the basis of clinical s

• br EL CONTEXTO DE LAS NEGOCIACIONES Y LA AGENDA BILATERAL

  2019-06-12

  

  EL CONTEXTO DE LAS NEGOCIACIONES Y LA AGENDA BILATERAL El avance de Cuba en el fortalecimiento de sus vínculos con América Latina y el Caribe ha sido destacado. En marzo y junio de 2009, Costa Rica y El Salvador, respectivamente, restablecieron relaciones diplomáticas con la Isla, con ello, toda

• br Genetic basis Similar to other arrhythmia syndromes Bruga

  2019-06-11

  

  Genetic basis Similar to other arrhythmia syndromes, Brugada and early repolarization syndromes are inherited diseases that are usually transmitted in an autosomal-dominant manner [26]. To date, 13 genes have been associated with Brugada syndrome. Loss-of-function mutations in SCN5A, encoding the

• Our group then carried out a study to

  2019-06-11

  

  Our group then carried out a study to determine the substrate sites and arrhythmogenic mechanisms of the BrS [29]. We found that all our BrS patients had abnormal low voltage, fractionated late potentials exclusively clustering in the anterior aspect of the RVOT epicardium and not seen anywhere else

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