• The root of Danshen has been widely used as traditional

  2022-06-06

  

  The root of (Danshen) has been widely used as traditional Chinese medicine for many years and shown to exhibit significant pharmacological activities for a variety of human diseases including cancers. Tanshinones, the major active components, belong to a group of an abietane-type diterpenes contain

• Cy5.5 NHS ester Furthermore the immunoassays described in ou

  2022-06-06

  

  Furthermore, the immunoassays described in our study showed excellent concordance of more than 93.33% with the LAg-Avidity EIA (Table 2). Using a panel of samples obtained from HIV-1 seroconverters over the course of up to 602 days post-infection, the gp41 peptide-based MP3 or MP4 assay identified s

• br Introduction Lysine acetylation is an important post tran

  2022-06-06

  

  Introduction Lysine acetylation is an important post-translational modification that is found on numerous cellular proteins, including both histone and non-histone proteins [1], [2]. Dynamic acetylation and deacetylation is regulated by enzymes called histone acetyltransferases (HATs) as writers

• br Material and methods br Results br Discussion HBV develop

  2022-06-05

  

  Material and methods Results Discussion HBV develops several strategies to suppress antiviral immune responses. Here, we used a bifunctional siRNA molecule to silence HBx and activate RIG-I, which induced HBV inhibition partly mediated by RIG-I in HBV-carrier mice. Furthermore, this 3p-siHB

• Toc and Toc are GTPases that regulate

  2022-06-05

  

  Toc34 and Toc159 are GTPases that regulate initial steps of preprotein import [3,4,26]. It was shown that GTP hydrolysis of at least one receptor is necessary to initiate the translocation process [23,27]. As reported for other small G-proteins, Toc34 and Toc159 bind their cargo in a nucleotide-depe

• br Conflict of Interest Both GM and

  2022-06-05

  

  Conflict of Interest Both GM and BDH are shareholders in Caldan Therapeutics, a company exploring potential novel treatments for type 2 diabetes. Acknowledgments Work described herein was supported by Biotechnology and Biological Sciences Research Council [grant BB/K019864/1)] (to GM) and [gr

• br Conclusion br Acknowledgements This

  2022-06-05

  

  Conclusion Acknowledgements This work was supported by a Grant-in-Aid for challenging Exploratory Research (15K12715) and was a partly supported by Suzuken Memorial Foundation (2014). The authors would like to thank Enago (www.enago.jp) for the English language review. G protein-coupled rec

• The inhibition of NSAIDs towards GLOI provides

  2022-06-05

  

  The inhibition of NSAIDs towards GLOI provides a direction for the development of novel effective GLOI inhibitors. Although the inhibitory activity of indomethacin was determined and the interactions between it CD 3254 and GLOI were probed by NMR titration experiments, no detailed inhibitory mechan

• Further research should indeed focus

  2022-06-05

  

  Further research should indeed focus on understanding the nutritional value of food and its effect on metabolism, overall activation of metabolic NRs network. Moreover, given the prominent role of microbiota in the modulation of the FXR signalling (Degirolamo et al., 2014), there is enough impetus t

• br Short Communication Free fatty acid receptors FFAR play s

  2022-06-05

  

  Short Communication Free fatty Pyrimethamine receptors (FFAR) play significant roles in energy metabolism (Brown et al., 2005; Ichimura et al., 2009). The receptor FFAR1 is involved in insulin secretion in humans (Meidute Abaraviciene et al., 2013). Activation of the receptor FFAR2 increases lip

• N6-Cyclopentyladenosine PBI is an agonist of

  2022-06-02

  

  PBI-4050 is an agonist of GPR40 and acts as an antagonist or inverse agonist of GPR84. It cannot be excluded that other targets besides GPR40 and GPR84 could be implicated in the mechanism of action of PBI-4050 and could be explored in future studies. However, the present study, and in particular th

• Most studies to date have focused on the physiological

  2022-06-02

  

  Most studies to date have focused on the physiological functions of FPS in plants. As mentioned above, numerous factors affect FPS expression and FPS function. However, FPS enzymatic assays require radiolabeled substrate and thus detailed enzymatic characterizations of FPS, including substrate speci

• Cell stiffness is determined by the cytoskeleton

  2022-06-02

  

  Cell stiffness is determined by the cytoskeleton, an intracellular polymeric network consisting of N1-Methylpseudo-UTP receptor filaments, microtubules, intermediate filaments, and crosslinking proteins [38]. Low cell stiffness has been correlated with reduced formation of well-defined F-actin fila

• br Conflict of interest br Introduction

  2022-06-02

  

  Conflict of interest Introduction HAT1 is the founding member of an expanding class of enzymes known as type B histone acetyltransferases (HATs). HATs are divided into two categories, type A and type B [1]. The type A HATs are nuclear enzymes that acetylate histones in the context of A-317491

• br Results br Discussion In

  2022-06-02

  

  Results Discussion In this study, we found that ZNF280A was elevated in CRC tissues and a high expression of ZNF280A correlated with advanced clinicopathological features, poor prognosis, and disease progression in CRC patients. Furthermore, silencing ZNF280A attenuated proliferation and inhib

11123 records 121/742 page Previous Next First page 上5页 121122123124125 下5页 Last page