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For the two KO models
2022-06-21
For the two KO models (CX30 and CX43), fluorescence recovery is almost always best fitted with a 2-component exponential (Fig. 6A and D). Statistical analysis of the parameters (Table 1) shows that in both cases the two time scales and the fraction of recovery associated with the fast intracellular
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Free fatty acids FFAs which are obtained from dietary
2022-06-21
Free fatty acids (FFAs), which are obtained from dietary fat or endogenous synthesis, function as nutrients and signaling molecules. Studies have shown that free fatty Progesterone receptors 1–4 which are G-protein coupled receptors, bind free fatty acids and serve as receptors for these FFAs. Shor
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br Acknowledgements We thank Kathy Spindler for helpful
2022-06-21
Acknowledgements We thank Kathy Spindler for helpful review of the manuscript. Expert technical assistance from Joel Whitfield in the University of Michigan Cancer Center Immunology Core is greatly appreciated. This research was supported by the American Heart Association (16GRNT30250013) and by
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Conformational analysis provides further insight into the SA
2022-06-21
Conformational analysis provides further insight into the SAR trends apparent in . Acyclic precursors – are 25–50-fold less active than their macrocyclic counterparts – against Pyk2. The global minima for – are conformations in which the –NHCH– linker between the pyrimidine and pyridine rings is sta
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PKC potentiates insulin release in beta cells however it
2022-06-21
PKC potentiates insulin release in beta cells; however, it is currently not clear how this is mechanistically accomplished in living 1661010 receptor [15]. First, we discuss PKC structure, regulation, and activation in beta cells. Then, we address two fundamental questions: (1) what is the specific
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Dysregulation of catecholaminergic neurotransmission particu
2022-06-20
Dysregulation of catecholaminergic neurotransmission, particularly the dopaminergic system, has long been correlated with the development of neuroinflammation and HAND. Studies specifically examining role of catecholamines in HIV pathogenesis, particularly focused on NeuroHIV, are relatively few. H
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The H R antagonist cimetidine
2022-06-20
The H2R antagonist cimetidine (Tagamet™) became the first billion-dollar drug in the 1980s for the treatment of peptic ulcer disease. Other H2R antagonists include ranitidine, famotidine, nizatidine, and zolantidine, the latter showing good BBB penetration with a steady-state brain/blood ratio of 1
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br Materials and methods br Results
2022-06-20
Materials and methods Results Discussion Type I ECa is associated with estrogen excess, obesity and hormone-receptor positivity. However, the function of ERα on ECa is considered complicated. The expression of ERα is reduced in grade III ECa clinical samples [13]. The high ERα expression is
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br Acknowledgements This work was supported by NIH HL
2022-06-20
Acknowledgements This work was supported by NIH HL111674 (JHF), and the Antoinette E. (“Mimi”) & Herman Boehm Foundation (JK). The authors wish to acknowledge the valuable assistance of the Functional Genomics Core of the University of Colorado, Denver. Introduction The 21-gene recurrence sco
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All the compounds and were assayed
2022-06-20
All the compounds –, , , –, , – and – were assayed for their potential cytotoxicity at a single dose of 10 µM on Huh7 cells. Interestingly, all compounds proved to be non toxic, with the exception of and which exhibited high cellular toxicity and therefore were excluded from further experiments (a
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br Concluding Remarks and Future Perspectives Our understand
2022-06-20
Concluding Remarks and Future Perspectives Our understanding of substrate targeting mechanisms utilized by kinases has grown tremendously in the past few years, but challenges still remain in relating these mechanisms to the organization of complex signaling networks. Substrate prediction based o
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br Introduction The discovery that the
2022-06-20
Introduction The discovery that the nitric oxide (NO), soluble guanylate cyclase (sGC), and cyclic guanosine monophosphate (cGMP) pathway mediates erection has led to the use of phosphodiesterase type 5 (PDE-5) inhibitors as the gold standard for treating erectile dysfunction (ED) through the inh
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Materials and methods Standard curve for
2022-06-20
Materials and methods Standard curve for methylglyoxal. Different concentrations (10, 25, 50, and 100μM) of pure MG (Sigma) were derivatized with 1,2-diaminobenzene and the absorbance of the resulting derivative was read by Cary 50 Bio UV-Visible spectrophotometer (Varian). One milliliter of total
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Using expression of TcMYH fused to
2022-06-20
Using expression of TcMYH fused to GFP, it was observed that MYH is present in the nucleus and in the mitochondrion of T. cruzi (Fig. 5). It is known that MYH protein from human, rat and mouse exhibits both mitochondrial and nuclear localization (Ichinoe et al., 2004, Lee et al., 2004, Nishioka et a
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Abnormal expression and higher activity of GLO I have
2022-06-20
Abnormal expression and higher activity of GLO I have been detected more in various tumor Lapatinib Ditosylate mg than in normal cell samples., , , , , , , Among cancer cell lines, lung carcinoma cells frequently showed higher GLO1 activity. Human NSCLC cell line NCI-H522 cells possess high activity
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